When a hurricane hits the Carolinas it uncovers two bodies, sharing uncanny similarities with a cold case in Quebec that has haunted Temperance Brennan for fifteen years.

At the same time, a rare bacterium that can eat human flesh is discovered in Charleston. Panic erupts and people test themselves for a genetic mutation that leaves them vulnerable.

With support from her long time partner Andrew Ryan, in a search that soon proves dangerous, Temperance discovers the startling connection between the victims of both murder cases - and that both the murders and the disease outbreak have a common cause...