This Safety Guide provides operating organizations that generate and manage radioactive waste as well as regulatory bodies and government bodies with recommendations on how to meet the requirements for the predisposal management of radioactive waste generated at nuclear power plants and research reactors (including subcritical and critical assemblies). It covers all stages in the lifetime of waste management facilities, including their siting, design, construction, commissioning, operation, and shutdown and decommissioning. It covers all steps carried out in the management of radioactive waste following its generation up to (but not including) disposal, including its processing (pre-treatment, treatment and conditioning). Radioactive waste generated during normal operation and in accident conditions is considered.