This publication provides practical guidance and information to Member States on how to manage nuclear safety knowledge at the national level, beyond the boundaries of individual organizations. It describes the underlying concepts, challenges and available approaches and tools, as well as summarizing the experience gained by Member States to date. The publication is in line with the ultimate objective of all nuclear safety knowledge management activities, which is to sustain and improve the competence of individuals and the capacity of organizations or countries to use such knowledge effectively and responsibly.