This publication advocates a “cities-based” approach to sustainable development which recognizes the central and integrating role that cities and urban living play in developing sustainability. It highlights that, similarly to the financial crisis of 2008, the COVID-19 (coronavirus) pandemic has shown that different cities have different capacities to cope with crises. Both crises disproportionally affected different cities and population groups; the most vulnerable suffering most. Cities need to develop innovative methods to confront infectious diseases without relying on drastic lockdown restrictions