This publication draws on data and results collated during an IAEA coordinated research project (CRP) on optimizing soil, water and nutrient use efficiency in integrated cropping-livestock production systems. The main objective of the project was to enhance food security, improve soil fertility, and mitigate greenhouse gases from agriculture using integrated cropping-livestock systems in changing climate conditions. In addition, the CRP participants developed a package of technology for farmers to increase crop production and improve their livelihoods using nuclear and related techniques.