Dr. Soetikno has organized a comprehensive issue devoted to the detection and diagnosis of non-polypoid colorectal neoplasms with special emphasis on sessile or flat colon adenoma. Top experts in the field have supplied the latest clinical information in the following areas: Non-Polypoid Colorectal Neoplasms in Ulcerative Colitis; Detection and Diagnosis of Non-Polypoid Colorectal Neoplasms; Image-Enhanced Endoscopy to Detect and Diagnose Non-Polypoid Colorectal Neoplasms; CT Colonography and Non-Polypoid Colorectal Neoplasms, as well as Endoscopic Mucosal Resection of Non-Polypoid Colorectal Neoplasms. This issue is an important one as there are not many references on the topics that are as comprehensive.