This edition of Psychiatric Clinics, guest edited by Drs. Scott T. Aaronson and Noah S. Philip, will cover a variety of essential topics surrounding Neuromodulation in psychiatric treatment. Articles discuss Electroconvulsive therapy for depression (and other conditions), Clinical applications and basic mechanisms for deep brain stimulation, clinical studies of Vagus Nerve Stimulation, Transcranial magnetic stimulation for Depression and other disorders, Transcranial Direct Current Stimulation, Neuromodulation in Children, Efficacy Analyses of Neuromodulation, and Future Stimulation approaches/considerations.