This textbook proposes an informal access to the most important issues of multidimensional differential and integral calculus. The traditional style—characterized by listing definitions, theorems, and proofs—is replaced by a conversational approach, primarily oriented to applications. The topics covered, developing along the usual path of a textbook for undergraduate courses, are always introduced by thoroughly carried out examples. This drives the reader in building the capacity of properly use the theoretical tools to model and solve practical problems. To situate the contents within a historical perspective, the book is accompanied by a number of links to the biographies of all scientists mentioned as leading actors in the development of the theory.