As developments in human genetics proceed apace,the regulation of genetic research and its applications is set to represent one of the major legal challenges of the next century. At every turn - in the fields of medicine and commerce, in insurance and employment, in the family and even in the criminal justice system - advances in human genetics threaten to transform our understanding of ourselves and the basis upon which we relate to one another. This special issue of the Modern Law Review addresses a range of key issues - conceptual, ethical, political and practical - arising from the regulatory challenge confronting the law in the face of the genetic revolution.