This issue of Primary Care: Clinics in Office Practice, guest edited by Drs. Rick Kellerman and Laura Mayans, is devoted to Gastroenterology. Articles in this issue include: Peptic Ulcer Disease, Gastritis and GERD; Gallbladder Dysfunction; Non Alcoholic Fatty Liver Disease (NAFLD); Pancreatic Cancer and Pancreatitis; Hepatitis A and Hepatitis B; Hepatitis C; Diverticular Disease; Irritable Bowel Syndrome; Inflammatory Bowel Disease; Celiac Disease and Gluten Sensitivity; Anorectal Disease and Hemorrhoids; Cancers of the Alimentary Tract - Esophagus, Stomach and Colon; and Emerging Concepts in GI Disease.