As nuclear power is one of the options that can be used to meet the growing energy demands of countries around the world, educating and enriching people with adequate knowledge on nuclear energy, nuclear reactor technologies, nuclear systems, reactor components and the embedded nuclear safety features are of paramount importance. Experience shows that education and training NPP simulators are effective tools that allow for a broad range of target groups to meet education and training objectives. It is the purpose of this publication to provide guidance based on the lessons learned from IAEA training courses on reactor technologies with the use of various NPP simulators. The main topics are classification of various types of NPP simulators for education and training, suitable selection of simulators according to assessment of education and training needs, and integration of simulators in to educational and training programmes to enhance knowledge based skills.