The latest developments in the field of Cardiac Resynchronization Therapy are featured in this issue of Heart Failure Clinics. Edited by Drs. Luigi Padeletti, Martina Nesti, and Giuseppe Boriani, the issue includes more than 20 articles in the following areas: heart failure; cost of heart failure; ventricular dissynchrony and resynchronization; assessment of dissynchrony; indication for CRT implantation; implantation technique; measures to improve CRT benefit on AF patients; and many more.