This issue of Veterinary Clinics of North America: Food Animal Practice is guest edited by Dr. Mike Apley on the topic of Bovine Therapeutics. Article subject areas include: Interpretation of bovine susceptibility, Pain control in cattle, Mastitis, Bovine respiratory disease, Enteric disease, Central nervous system disease, Pinkeye, Genitourinary Problems, Musculoskeletal Problems, and the use of metrics to evaluate therapeutic evidence.