In The Pacemaker Channels of the Heart, Denis Noble chronicles the fascinating journey of his research into one of biology's most essential functions — the rhythmic beating of the heart. Written by the founder of mathematical heart modelling, this book traces scientific developments spanning over sixty-five years, from the pioneering 1960 heart rhythm model to the sophisticated integrative models of today. This journey follows the evolution of cardiac electrophysiology through the discovery of potassium and slow channels, analytical modelling, and the development of the electrocardiogram.Beyond its technical scope, the book describes a profound shift in biological thinking — from a reductionist, gene-centric view of life to a systems-based understanding of living organisms. In doing so, it addresses major philosophical and scientific debates surrounding the foundations of biology, offering a fresh perspective on why genes alone cannot account for the complexity of life. The book will be of great interest to researchers and students specialising in cardiology, as well as philosophers of science and more general readers, presenting a synthesis of rigorous research, theoretical innovation, and wider reflections on a storied career in the biological sciences.