This issue of Perioperative Nursing Clinics, Guest Edited by Katherine Gaberson, PhD, RN, CNOR, on the topic of Surgical Instruments will include the following article topics: History of Surgical Instruments; Nursing Role in Creating New Instruments; Best Practices Related to Instrument Counts; Innovations in Instrument Care; Evidence Base for Hands-Free Techniques; Evidence Base for Sharps Design to Prevent Injury; Robotic Surgery Instrumentation; Instrument Readiness as a Patient Safety Issue; Cost Analysis of Outsourcing Instrument Repair and Refurbishing; Innovative Techniques for teaching Instrumentation; Best Practices for Reducing Instrument Loss; Providing Surgical Instruments for Medical Missions; and Humor Involving Surgical Instruments.