This publication presents a comprehensive overview of various aspects relating to the application of cogeneration with nuclear energy, which may offer advantages such as increased efficiency, better cost effectiveness, and reduced environmental impact. The publication provides details on experiences, best practices and expectations for the foreseeable future of cogeneration with nuclear power technology and serves as a guide that supports newcomer countries. It includes information on systems and applications in various sectors, feasibility aspects, technical and economic details, and case studies.