This issue of Primary Care: Clinics in Office Practice, guest edited by Drs. Gretchen Irwin and Laura Mayans, is devoted to Urology. Articles in this issue include: Dysuria; UTI and Pyelonephritis; Nephrolithiasis; Interstitial Cystitis; BPH; Urinary Incontinence; Enuresis; Erectile Dysfunction; Prostate Cancer Screening; Hematuria; and Urologic Cancers.