The publication seeks to deepen the understanding of the impact of rapid technological change on sustainable development, especially the consequences for the central principle of the 2030 Agenda of “leaving no one behind”, and the implications for the science, technology and innovation community. It examines the opportunities, risks and challenges brought about by rapid technological change, and looks at the role of science, technology and innovation (STI) policy. It identifies strategies, policies and immediate actions to take to use science, technology and innovation to empower people, especially those who are vulnerable, and ensure inclusiveness and equality.