In this issue, Guest Editors Pratik Panharipande and Wesley Ely look at modern Sedation techniques in the critically ill. Topics include: "Pharmacology of commonly used sedatives and analgesics in the ICU," "Pharmacology of newer agents for sedation and analgesia in the critically ill," "Current sedation practices: lessons learned from recent international surveys," "Sedation and Immunomodulation," "Sedation and sleep disturbances in the ICU," and more!