It is essential to minimize damage to normal tissues during radiation therapy and many strategies have been employed in finding the best methods for radioprotection. This book integrates chemical, biological, and clinical perspectives on these strategies and developments, providing a comprehensive treatise. It emphasizes new concepts in radioprotection, aiming to inspire further basic science and clinical progress in radioprotector research. Radioprotectors: Chemical, Biological, and Clinical Perspectives includes the following topics:
Early research on radioprotectors
WR-2721, an aminothiol prodrug, as a radioprotector
New results with naturally occurring thiols
Nitroxides as effective radioprotectors in vitro and in vivo
Radioprotection observed with radical scavengers or antioxidants
Bone marrow radioprotection with cytokines and biological modifiers
Multiple mechanisms of altering radiation response by eicosanoids
Vascular response to radiation and the importance of vascular damage to normal tissue
Modifiers of radiation-induced apoptosis
Survey of clinical trials with radioprotectors
Radiation biologists and oncologists, cancer researchers, and toxicologists will benefit from the findings discussed and strategies for future research.