This book provides an up-to-date summary of the principles of protein evolution and discusses both the methods available to analyze the evolutionary history of proteins as well as those for predicting their structure-function relationships.

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• Includes a significantly expanded chapter on genome evolution to cover genomes of model organisms sequenced since the completion of the first edition, and organelle genome evolution
  
• Retains its reader-friendly, accessible style and organization
  
• Contains an updated glossary and new references, including a list of online reference sites