This issue of Infectious Disease Clinics of North America, Guest Edited by Mary Anne Jackson, MD and Angela Myers, MD, is Part I of a 2-part issue devoted to Pediatric Infectious Diseases. Drs. Jackson and Myers have assembled a group of expert authors to review the following topics: Diagnosis and Management of Kawasaki Disease; Neonatal HSV Infection; Use of Newer Diagnostics for Pediatric Tuberculosis; Recognition and Prompt Treatment for Tick Borne Infections; Prevention of Recurrent Staphylococcal Skin Infections; Evaluation and Management of the Febrile Young Infant; New Horizons for Pediatric Antimicrobial Stewardship; Pitfalls in Diagnosis of Pediatric Clostridium Difficile Diarrhea; The Changing Epidemiology of Pediatric Endocarditis; Neonatal Parechovirus Infection; Osteoarticular infections in Children; and Pediatric CMV Disease.