Intra-uterine insemination (IUI) is a widely used fertility treatment for couples with unexplained and male subfertility. Although it is less invasive and less expensive as athan several other treatment options, than in vitro fertilization, severalsome points about the factors affecting its outcomeIUI remain controversial and there remains concern about some of the possible aspects of treatmentside-effects, such as an increase in multiple pregnancy rates. This is a comprehensive evidence-based book from an international IUI expert team, with guidelines for daily practice clearly stated and summarized for readers’ convenience.