This book offers an original hypothesis capable of unifying evolution in the physical universe with evolution in biology; herewith it lays the conceptual foundations of “transdisciplinary unified theory”. The rationale for the hypothesis is presented first; then the theoretical framework is outlined, and thereafter it is explored in regard to quantum physics, physical cosmology, micro- and macro-biology, and the cognitive sciences (neurophysiology, psychology, with attention to anomalous phenomena as well). The book closes with a variety of studies, both by the author and his collaborators, sketching out the implications of the hypothesis in regard to brain dynamics, cosmology, the concept of space, phenomena of creativity, and the prospects for the elaboration of a mature transdisciplinary unified theory. The Foreword is written by philosopher of science Arne Naess, and the Afterword is contributed by neuroscientist Karl Pribram.