This issue of Primary Care: Clinics in Office Practice, guest edited by Dr. Michael Malone, is devoted to Infectious Disease. Articles in this issue include: Tick-borne Illnesses; Mosquito-Borne Diseases; Mite and Bed Bug Infections; Pertussis; Skin and Soft Tissue Infections; UTI Antibiotic Resistance in the U.S; Emergence of Global Antibiotic Resistance; Guidelines for the Evaluation and Treatment of Pneumonia; Common Central Nervous System Infections; Common Gastrointestinal Infections; Role of Complimentary and Alternative Therapies in Infectious Disease; Health Guidelines for Travel Abroad; Aquatic Infections; and Infections During Pregnancy.