The success of any pharmacy organization is directly connected to the strength of its workforce. Effective and principled human resource management is essential to unleash the full potential of pharmacists, technicians and other staff who will help an organization thrive and grow. Understanding and gaining confidence in applying theories of organizational and behavioral psychology to build an engaged and competent workforce is necessary for all managers, supervisors, and leaders. Leveraging the power of effective human resource management in leading change and transforming organizations can help the pharmacy profession—in all its diverse settings—to grow and prosper.