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The year is 1878. Dr. Alexander Potter, disgraced Civil War surgeon, now huckster and seller of snake-oil, travels the wet roads of the Pacific Northwest with a disheartened company of strongmen, illusionists, fortunetellers, and musical whores. Under the quiet command of the mysterious, merciless, and murderous Lyman Rhoades, they entertain the masses while hawking the Chock-a-saw Sagwa Tonic, a vital elixir touted to cure all ills both physical and spiritual ...although, for a few unfortunate customers, the Sagwa offers something much, much worse. For drunken dentist Josiah McDaniel, the Sagwa has taken everything from him; in the hired company of two accidental outlaws, the bickering brothers Solomon Parker and Agamemnon Rideout, he looks to revenge himself on the Elixir's creator: Dr. Morrison Hedwith, businessman, body-thief, and secret alchemist, a man who is running out of time.