This issue of Medical Clinics of North America, Guest Edited by Douglas S. Paauw, MD is devoted to Comprehensive Care of the Patient with Chronic Illness. Dr. Paauw has assembled a group of expert authors to review the following topics: Primary Care of the Homeless Patient; Primary Care of the Patient with Chronic Liver Disease; Primary Care of the Transplant Patient; Primary Care of the Patient with CRI; Primary Care of the Patient with Alcoholism; Primary Care of the Childhood Cancer Survivor; Primary Care of the Immigrant Patient; Primary Care of the HIV Patient; Primary Care of the Patient with Chronic Lung Disease; Primary Care of the Patient with Sarcoid; and Primary Care of the Patient with Inflammatory Bowel Disease.