This issue of the Interventional Cardiology Clinics edited by Michael Lee covers all key aspects of complex coronary intervention. Topics include, but are not limited to: Saphenous Vein Interventions, Atherectomy Devices for the Treatment of Calcified Lesions, Bifurcation Stenting, Chronic Total Occlusion, Multivessel Coronary Artery Disease, Management of Complications (Perforation/Dissection/Thrombosis), Antithrombotic Therapy in Percutaneous Coronary Intervention, and Acute Myocardial Infarction/Thrombectomy.