This issue of Psychiatric Clinics, edited by Drs. Stefan G. Hofmann and Jasper Smits, will focus on Cognitive Behavioral Therapy for Anxiety and Depression. Topics covered in articles in this issue include, but are not limited to: Basic strategies of CBT; Core mechanisms of CBT; CBT for anxiety and depression in severe mental disorders; Unified treatment for anxiety disorders; Internet-assisted CBT; Cultural adaptions of CBT; Pharmacological enhancements of CBT; and Current status and future directions of CBT.