This volume distinguishes itself by focusing specifically on biofilm-associated infections within the context of the infectious microenvironment. Rather than providing a general overview, it integrates host–pathogen interactions, polymicrobial complexity, and microenvironmental heterogeneity to frame biofilms as dynamic drivers of chronic and treatment-refractory disease.

Interest in the biofilm mode of microbial growth has evolved into a central paradigm in infection biology. Since the concept was introduced by J. William Costerton and later recognized by the American Society for Microbiology as a distinct mode of growth, the field has expanded substantially, with numerous books addressing biofilm structure, physiology, and antimicrobial tolerance.

Authored by leading experts, the book provides a critical and up-to-date synthesis of biofilm involvement across diverse clinical settings, while highlighting emerging diagnostic and therapeutic strategies. It is intended for researchers and clinicians seeking a mechanistic and translational perspective on biofilm infections within modern biomedical science.