This issue of Dermatologic Clinics, guest edited by Dr. John J. DiGiovanna, is devoted to Skin Science Contributions in Clinical Dermatology. Articles in this issue include Mosaic mTORopathies; CYLD: Cause and Therapeutic Target for Cylindromas; Current Status of Dedicator of Cytokinesis (DOCK), DOCK8, DOCK2; IL-22 relation to Tumor Aggression and Role of Cyclosporine; Dual Lineage of Dermal Fibroblasts and Potential for Scar Correction, Reformation of Adnexal Structures; Inflammasome Instigated Autoinflammatory Disorders; Pigment Cell Biology; Antimicrobial Peptides; and Choosing Friend or Foe? Commensal-specific tolerance.