This publication presents a new and extended analysis of the regional risk-scape based on multidisciplinary research conducted. It defines risk hotspots where disasters and biological hazards, climate and health emergencies – including Covid-19 – collide. It further presents the emergence of new systemic risks and cascading hazards, alongside their impacts on peoples and economies. Identifying regional and sub-regional gaps in building resilience into the disaster-health-climate nexus, the report provides tailored, sub-regional insights into opportunities for policy actions and operational solutions to build back better with resilience. The ability to identify and address the unmet needs of those furthest behind within the new risk-scape is also considered here, as is the fiscal cost of a resilience agenda for the region.