These proceedings are the result of a conference on advances in radiation oncology. The aim of the conference was to discuss and define the current role and future potential of medical physics and molecular/biological innovations in routine clinical practice in radiation oncology. It also provided a forum where advances in technology, best practices and quality assurance methodologies were disseminated and scientific knowledge exchanged. The publication presents a summary of the topical sessions and highlights the main conclusions and recommendations that were discussed during the conference.