Despite technical advances using MR and the emergence of PET imaging, CT continues to be a frequently used imaging modality that has not stood still while others have thrived. Advances in CT have continued apace with other modalities which have taken CT into new areas of imaging that just a few short years ago it could not approach. With the advent of 64-slice CT, a greater number of images can be taken in a much quicker period of time. The use of CT perfusion in the brain and abdomen are reviewed in this issue. Cutting edge techniques such as 4D CT and dual energy CT will be discussed, as well as CT applications for imaging of the coronary arteries and cardiac valves.