Colonoscopy is the bread and butter for endoscopists and advances in the procedure to reduce time, improve efficiency, and prevent errors are very important for this group. The newest advances look at colonoscopy efficiency and a better way to target tissue sampling, which avoids random biopsies and instead looks at ways to predict areas for sampling. The Guest Editors have selected top experts to provide these important updates and they also address current thinking that questions the continued value of colonoscopies as predictors of colon cancer. The issue will be a very popular one, and it needs to be heavily promoted.