Far from being the sole mode of explaining, explanation in terms of – mostly probabilistic – causes has nourished a wide debate addressing diseases, what produces them and how. Focusing on causal explanations involves, in turn, getting deeper into conceptions of causation, modelling, and control, and presents a range of relevant issues for research and clinical contexts. The aim of the volume is two-fold. In the first place, its purpose is to stress core features, differences and interactions between various theories belonging to, on the one hand, the mechanical and neo-mechanical approach to explanation, and, on the other hand, the interventionist approach, testing their suitability in medicine. In the second place, and related to the first, a form of pluralism is advocated which is grounded on a deep analysis of specific features of explanatory contexts in the health sciences, especially in cancer and mental health studies.