The role of ultrasound in interventional procedures continues to expand in tandem with refinements of sonographic technology. This issue of Ultrasound Clinics includes the following articles: Ultrasound-Guided Breast Interventions, Ultrasound-Guided Procedures in Obstetrics; Ultrasound-Guided Transvaginal Procedures; Ultrasound-Guided Visceral Biopsies: Renal and Hepatic; Ultrasound-Guided Abscess Drainages; Ultrasound-Guided Intraoperative and Percutaneous Tumor Ablation; Ultrasound-Guided Vascular Access; Ultrasound-Guided Biliary Interventions: Percutaneous Biliary Drains and Cholecystostomies; Percutaneous Nephrostomy; Ultrasound-Guided Management of Vascular Access Pseudoaneurysms.