The COVID-19 pandemic represents an important watershed for modern society. The world will never be the same. Almost all economic and social activities need to be reviewed, rethought, and adapted to the new context. The COVID-19 Disruption and the Global Health Challenge explains a complex phenomenon that has left doubts and uncertainties among the many who want to understand. The book fills some of these gaps by providing answers to a series of questions including why the epidemic originated, how it spread, how it was managed, how long we will have to live with it, what effects did it have on the economy, who will be most affected, how the new world will change us, and how our way of seeing the world will change. Lastly, the book proposes some solutions to prevent and be more prepared to the recurrence of such events as well as to manage them more effectively.