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Sabrina disappears. This immediately gives rise to a bunch of conspiracy theories, because you can't just live in a world where bad things happen - you have to come up with explanatory schemes, which are ultimately more monstrous in their consequences than the event itself. All in all, a very quiet and very hopeless comic about the information background we live in.
But this particular faded narrative is even more in tune with the zeitgeist now than when Drnaso wrote and drew the book in 2017, when GQ called it "the first great work about our age of disinformation, paranoia, and fake news" and the Booker Prize decided to longlist the comic for the first (and so far last) time. Conspiracy theories, nervous breakdowns, murder - everything will be fine until it isn't. "Sabrina shows a modern world that avoids personal contact and responsibility, where relationships are devoid of intimacy and take place through the glow of electronic screens.