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The textbook covers the history of the development of the doctrine of rheumatism, the priority of the Ukrainian scientist Volkovynskyi F.I. in the study of rheumatism, a review of the world literature on the problems of diagnosis and therapy of rheumatism, features of the clinic, diagnosis and treatment of acute rheumatic fever and chronic rheumatic heart disease, current data and prospects for further research in the study of this disease. The textbook will be useful for students of higher education of III-IV accreditation levels, postgraduate students, doctors of various medical specialities - rheumatologists, cardiologists, family doctors.