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The article presents a methodology for assessing the effectiveness of innovation and investment projects at domestic industrial enterprises, taking into account the use of pre-planning assessment tools and economic rent. The theoretical provisions, methodological and practical aspects of creating an effective system for managing the activities of business structures are substantiated. The main tools for improving the quality management system are highlighted. The mechanism of potential management in modern conditions is considered, the structure, principles and stages of potential formation, as well as directions of anti-crisis management of the enterprise potential are presented. The issues discussed in the monograph are of interest to teachers, postgraduates and students specialising in innovation, strategic and production management, for practical use in enterprise management.