Manual of Chronic Total Occlusion Percutaneous Coronary Interventions: A Step-by-Step Approach, Third Edition is a practical reference for coronary chronic total occlusion (CTO) percutaneous coronary interventions (PCI). Written by recognized national and international experts in the field, this reference compiles the steps necessary to preform, what pitfalls to watch out for, and how to troubleshoot tactics. Written to bring a practical approach, this book is perfect for interventional cardiologists, interventional and general cardiology fellows, cardiology researchers, physicians, cardiac catheterization laboratory personnel, technical staff, industry professionals and everyone else interested in understanding the cutting-edge and rapidly evolving field of CTO PCI. In this new edition, new figures, images and algorithms have been developed to reflect the updates in CTO PCI during the past few years. In addition, this update links to approximately 200 CTO PCI cases that are accessible for free and hosted by the author on YouTube, with monthly updates on new cases. The structure of the book is completely revised to align it with the recently published Manual of Percutaneous Coronary Interventions (published in Oct 2020, also by Dr. Brilakis under the same imprint Academic Press).