After her parents leave to care for her ailing grandmother, high schooler Miko "Meeko" Sonoda moves into her uncle's boarding house. There, she meets its rather unusual residents, including the oldest of the bunch: the grumpy mother hen Matsunaga-san. With the help of her housemates, Meeko begins to adjust to her new life away from her parents, but Meeko soon learns that no matter how far away from home she is, she's still a young girl at heart, especially when she finds herself falling for Matsunaga-san.