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After a violent argument with her mother, Holly Sykes closes the doors of her parents' house and her past life forever. But she is not just a stubborn teenage rebel. As a child, Holly had "weird stuff" happen to her, like the voices of the Radio People in her head. And though she's supposedly "cured," the mystery of one lost weekend will resurface every decade-from the turbulent 1980s to the apocalyptic 2040s-affecting the people she loves, and even those who have yet to be born.

An ambitious Cambridge political science masters student; a war reporter; a renowned author - all play a role not only in Holly Sykes' life, but in the bizarre war of the immortals for the souls of the bone clocks.

This novel by the acclaimed author of Cloud Atlas is impossible to put down. It is at once comprehensive and precisely ordered, full of life and imbued with an awareness of its transience and value. It is a journey through time, cultures and genres.