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World-renowned expert on religious symbolism Robert Langdon is urgently summoned to Switzerland to investigate a mysterious sign burned on the chest of a brutally murdered physicist. He makes a startling discovery: it is the work of the Church's old enemy, the secret Illuminati organisation. In addition, a powerful bomb has been planted in the Vatican, which must be found by Landon, along with a charming female scientist, Vittoria Vetra.

A crazy adventure awaits them: following the trail of a ruthless killer, collecting corpses, climbing cathedrals, descending into dungeons to finally find the Illuminati lair and save the Holy See.