This publication presents the latest update to the INPRO methodology for Nuclear Energy Systems sustainability assessment in the area of waste management and reflects detailed discussions held at an IAEA technical meeting. Waste generated by nuclear energy systems and considered in this publication includes all classes and categories of waste from nuclear power plants and nuclear fuel cycle facilities over the course of normal operations and anticipated operational occurrences. It is anticipated that the information presented in this and other INPRO publications, for example IAEA Nuclear Energy Series No. NG-T-3.12, will assist in the identification of areas for improvement in nuclear energy systems.