This issue of Clinics in Perinatology, guest edited by Dr. Hanmin Lee, examines the topic of Fetal Surgery. The issue begins with an overview, including the history of fetal surgery, ethical implications, and maternal management and outcome. Imaging (including Ultrasound, MRI, and Echocardiology) and Specific Diseases (including Congenital Diaphragmatic Hernia, Fetal Lung Lesions, Obstructive Uropathy, TTTS, MMC, TRAP and other discordant twins, and Congenital Cardiac Anomalies) are also examines. The issue concludes with a look at research and future directions, including Stem Cell Transplant/Gene Therapy, Consortiums/Registries, and Fetal Tissue Engineering.