A young girl goes missing after getting into a car with a mysterious man. Soon after, a second girl disappears, and her devastated father, Witness, sets out to seek revenge.

As the trail goes cold, Samantha Khama new recruit to the Botswana Criminal Investigation Department suspects the girl was killed for muti, the traditional African medicine usually derived from plants, sometimes animals, and, recently and most chillingly, human parts.

When the investigation gets personal, Samantha enlists opera-loving wine connoisseur Assistant Superintendent David 'Kubu' Bengu to help her dig into the past.

As they begin to discover a pattern to the disappearances, there is another victim, and Kubu and Samantha are thrust into a harrowing race to stop a serial killer who has only one thing in mind.