Jack Sheppard - a transgender carpenter's apprentice - has fled his master's house to become a notorious prison break artist, and Bess Khan has escaped the draining of the fenlands to become a revolutionary mastermind. Together, they find themselves at the center of a web of corruption leading back to the dreaded Thief-Catcher General ...

...Or so we are told in a mysterious manuscript unearthed by one Professor R. Voth. Voth traces the origins and authenticity of the manuscript as Jack and Bess trace the connections between the bowels of Newgate Prison and the dissection chambers of the Royal College, in a bawdy collision of a novel about gender, love, and liberation.